当前位置: X-MOL 学术Chem. Biol. Interact. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Potential of siRNA-albumin complex against cancer
Chemico-Biological Interactions ( IF 5.1 ) Pub Date : 2018-04-27
Na Liu, Yan-Hua Qi, Chuan-Tao Cheng, Wen Bin Yang, Anshoo Malhotra, Qi Zhou

RNA interference is a highly specific as well as efficient technology for gene therapy application in molecular oncology. The present study was planned to develop an efficient and stable tumor selective delivery mechanism for siRNA gene therapy for the purpose of both diagnosis as well as therapy. We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). The study results confirmed efficient delivery of siRNA at tumor site as confirmed by tagging of siRNA-albumin complex with 99mTC. Moreover, the expression of VEGF also showed decline after efficient delivery of siRNA at tumor site. The study concluded that albumin is an efficient molecule for the efficient delivery of siRNA at tumor sites.



中文翻译:

siRNA-白蛋白复合物抗癌的潜力

RNA干扰是基因疗法在分子肿瘤学中的一种高度特异性且有效的技术。本研究计划开发用于siRNA基因治疗的有效且稳定的肿瘤选择性递送机制,以用于诊断和治疗。我们已经使用了20只雄性Wistar大鼠来建立结肠癌模型,并利用白蛋白作为载体分子来递送针对血管内皮生长因子受体2(VEGF R2)的siRNA。该研究结果证实了siRNA在肿瘤部位的有效递送,这是通过siRNA-白蛋白复合物标记99m证实的。TC。而且,在肿瘤部位有效递送siRNA后,VEGF的表达也显示下降。研究得出结论,白蛋白是在肿瘤部位有效传递siRNA的有效分子。

更新日期:2018-04-28
down
wechat
bug