p-Cresyl glucuronide (p-CG) is a by-product of tyrosine metabolism that accumulates in patients with end-stage renal disease. p-CG binding to human serum albumin in physiological conditions (37°C, pH 7.40) was studied by ultrafiltration (MWCO 10 kDa) and data were analyzed assuming one binding site. The estimated value of the association constant was 2.77×10³ M^-1 and a maximal stoichiometry of 3.80 mol per mole. At a concentration relevant for end-stage renal patients, p-CG was 23% bound to albumin. Competition experiments, using fluorescent probes, demonstrated that p-CG did not bind to Sudlow's site I or site II. The p-CG did not interfere with the binding of p-cresyl-sulfate or indoxyl sulfate to serum albumin.

p-Cresyl葡糖醛酸苷（p-CG）是酪氨酸代谢的副产物，可在患有终末期肾脏疾病的患者中累积。通过超滤（MWCO 10 kDa）研究了在生理条件（37°C，pH 7.40）下p-CG与人血清白蛋白的结合，并假设一个结合位点对数据进行了分析。缔合常数的估计值为2.77×10 ³  M ^-1，最大化学计量为3.80摩尔/摩尔。在与终末期肾病患者相关的浓度下，p-CG与白蛋白的结合率为23％。使用荧光探针的竞争实验表明，p-CG不与Sudlow的I位或II位结合。p-CG不会干扰对甲酚基硫酸盐或吲哚基硫酸盐与血清白蛋白的结合。