Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.

中文翻译：

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来自内胚层真菌Phoma sp的抗炎性phomalichenones。

从苔藓内生真菌Phoma sp。的培养物中分离出四种新化合物，phomalichenones AD（1-4）和七个已知化合物（5-11）。EL002650。通过分析其光谱数据（NMR和MS）确定它们的结构。化合物1和6抑制了脂多糖（LPS）刺激的RAW264.7巨噬细胞中一氧化氮（NO）的产生。此外，化合物1降低了诱导型一氧化氮合酶（iNOS）和环氧合酶2（COX-2）的蛋白质表达水平，并降低了促炎细胞因子，例如肿瘤坏死因子-α（TNF-α）的mRNA表达水平。 α），白介素（IL）-1β和IL-6。