Microorganisms interact chemically in natural environments; however, the compounds and mechanisms involved in this phenomenon are still poorly understood. Using the cocultivation approach, changes in metabolic profiles due to interactions between endophytic fungal and actinobacterial strains isolated from the plant Lychnophora ericoides (Asteraceae) were assessed. The production of the cytotoxic compound cytochalasin H by the fungus Phomopsis sp. FLe6 was remarkably inhibited in solid and liquid co-cultures with the actinobacteria Streptomyces albospinus RLe7. This was a consequence of the fungal growth inhibition caused by antifungal compounds produced by S. albospinus RLe7, including amphotericin B. Cytochalasin H is not toxic to S. albospinus RLe7, suggesting that this microorganism does not require a defense mechanism to prevent the potentially harmful effects of such fungal compound. By exhibiting various competitive phenotypes, these microbes can control each other’s growth when sharing an environment.

微生物在自然环境中发生化学相互作用。但是，这种现象所涉及的化合物和机理仍知之甚少。使用共培养的方法中，由于内生真菌和从植物中分离的放线菌菌株之间的相互作用的变化中代谢概况胖大海ericoides（菊科）进行了评估。真菌Phomopsis sp。产生的细胞毒性化合物cytochalasinH 。FLe6在放线菌链霉菌链霉菌RLe7的固液共培养中受到显着抑制。这是由链球菌RLe7产生的抗真菌化合物（包括两性霉素B）引起的真菌生长抑制的结果。S. albospinus RLe7，表明该微生物不需要防御机制来防止此类真菌化合物的潜在有害作用。通过展现各种竞争表型，这些微生物可以在共享环境时控制彼此的生长。