Journal of the American Academy of Child and Adolescent Psychiatry ( IF 13.3 ) Pub Date : 2018-04-17 Sophie A. Palitz, Nicole E. Caporino, Joseph F. McGuire, John Piacentini, Anne Marie Albano, Boris Birmaher, John T. Walkup, Scott N. Compton, Golda S. Ginsburg, Philip C. Kendall
Objective
To determine the percent reduction cutoff on the Multidimensional Anxiety Scale for Children (MASC) that optimally predict treatment response and remission in youth with anxiety disorders.
Method
Youths and their parents completed the MASC-C/P pre- and post-treatment, and the Anxiety Disorders Interview Schedule for DSM-IV–Child and Parent Versions (ADIS-IV-C/P) and Clinical Global Impression – Improvement scale (CGI-I) were administered by independent evaluators. Treatment response and remission were defined by posttreatment ratings on the CGI-I and the ADIS-IV-C/P, respectively. Quality receiver operating characteristic methods determined the optimal cutoff on the MASC-P for predicting overall remission (loss of all study entry diagnoses), and optimal percent reductions on the MASC-P for predicting treatment response and remission of separation anxiety, social anxiety and generalized anxiety.
Results
A posttreatment raw score of 42 optimally predicted remission. A reduction of 35% on the total MASC-P predicted treatment response. A reduction of 30% on the Separation Anxiety/Panic subscale of the MASC-P predicted separation anxiety remission. A reduction of 35% on the Social Anxiety subscale of the MASC-P predicted social anxiety remission. The MASC did not evidence a cutoff for remission of Generalized Anxiety Disorder.
Conclusion
MASC cutoffs can facilitate comparison across studies and guide practice, aiding clinicians in assessing progress and informing treatment plans.
中文翻译:
定义青少年焦虑症的治疗反应和缓解:儿童多维焦虑量表的信号检测分析
客观的
为了确定儿童多维度焦虑量表(MASC)的减少百分比临界值,该量表可以最佳地预测患有焦虑症的青年的治疗反应和缓解情况。
方法
青年及其父母完成了MASC-C / P的治疗前后,以及DSM-IV-儿童和父母版本的焦虑症访谈时间表(ADIS-IV-C / P)和临床总体印象-改善量表( CGI-1)由独立的评估人员进行管理。通过CGI-I和ADIS-IV-C / P上的治疗后等级分别定义治疗反应和缓解。质量接收器操作特征方法确定了MASC-P的最佳临界值,以预测总体缓解(所有研究入学诊断的损失),以及MASC-P的最佳降低百分比,以预测治疗反应和分离性焦虑,社交焦虑的缓解以及广义焦虑。
结果
治疗后原始评分为42最佳预测缓解。总MASC-P预测的治疗反应降低35%。MASC-P的分离焦虑/恐慌子量表的降低30%可以预测分离焦虑的缓解。MASC-P的社交焦虑子量表减少35%可以预测社交焦虑症的缓解。MASC没有证据表明普遍焦虑症的缓解已经中断。
结论
MASC的分界值可以促进跨研究的比较和指导实践,帮助临床医生评估进展并告知治疗计划。