Electrochemical molecularly imprinted polymers (e-MIPs) were for the first time introduced in screen-printed carbon electrodes (SPCE) as the sensing element for the detection of an organic pollutant. To play this sensing role, a redox tracer was incorporated inside the binding cavities of a cross-linked MIP, as a functional monomer during the synthesis step. Ferrocenylmethyl methacrylate was used for this purpose. It was associated with 4-vinylpyridine as a co-functional monomer and ethylene glycol dimethacrylate as cross-linker for the recognition of the endocrine disruptor, Bisphenol A (BPA), as a target. Microbeads of e-MIP and e-NIP (corresponding non-imprinted polymer) were obtained via precipitation polymerization in acetonitrile. The presence of ferrocene inside the polymers was assessed via FTIR and elemental analysis and the polymers microstructure was characterized by SEM and nitrogen adsorption/desorption experiments. Binding isotherms and batch selectivity experiments evidenced the presence of binding cavities inside the e-MIP and its high affinity for BPA compared to carbamazepine and ketoprofen. e-MIP (and e-NIP) microbeads were then incorporated in a graphite-hydroxyethylcellulose composite paste to prepare SPCE. Electrochemical properties of e-MIP-SPCE revealed a high sensitivity in the presence of BPA in aqueous medium compared to e-NIP-SPCE with a limit of detection (LOD) of 0.06 nM. Selectivity towards carbamazepine and ketoprofen was also observed with the e-MIP-SPCE.

电化学分子印迹聚合物（e-MIPs）首次引入丝网印刷碳电极（SPCE）中，作为检测有机污染物的传感元件。为了发挥这种感测作用，在合成步骤中，氧化还原示踪剂被掺入到交联的MIP的结合腔内，作为功能单体。为此使用甲基丙烯酸二茂铁基甲基丙烯酸酯。它与4-乙烯基吡啶作为共官能单体和乙二醇二甲基丙烯酸酯作为交联剂相关联，以识别内分泌干扰物双酚A（BPA）作为靶标。通过在乙腈中沉淀聚合获得e-MIP和e-NIP（相应的非印迹聚合物）的微珠。通过FTIR和元素分析评估了聚合物中二茂铁的存在，并通过SEM和氮吸附/解吸实验表征了聚合物的微结构。结合等温线和批次选择性实验证明，与卡马西平和酮洛芬相比，e-MIP内部存在结合腔，并且对BPA的亲和力高。然后将e-MIP（和e-NIP）微珠掺入石墨-羟乙基纤维素复合浆料中以制备SPCE。与e-NIP-SPCE相比，e-MIP-SPCE的电化学性能显示在水介质中存在BPA时具有很高的灵敏度，检测限（LOD）为0.06 nM。用e-MIP-SPCE还观察到了对卡马西平和酮洛芬的选择性。结合等温线和批次选择性实验证明，与卡马西平和酮洛芬相比，e-MIP内部存在结合腔，并且对BPA的亲和力高。然后将e-MIP（和e-NIP）微珠掺入石墨-羟乙基纤维素复合浆料中以制备SPCE。与e-NIP-SPCE相比，e-MIP-SPCE的电化学性能显示在水介质中存在BPA时具有很高的灵敏度，检测限（LOD）为0.06 nM。用e-MIP-SPCE还观察到了对卡马西平和酮洛芬的选择性。结合等温线和批次选择性实验证明，与卡马西平和酮洛芬相比，e-MIP内部存在结合腔，并且对BPA的亲和力高。然后将e-MIP（和e-NIP）微珠掺入石墨-羟乙基纤维素复合浆料中以制备SPCE。与e-NIP-SPCE相比，e-MIP-SPCE的电化学性质显示了在水介质中存在BPA的情况下具有高灵敏度，检测限（LOD）为0.06 nM。用e-MIP-SPCE还观察到了对卡马西平和酮洛芬的选择性。然后将e-MIP（和e-NIP）微珠掺入石墨-羟乙基纤维素复合浆料中以制备SPCE。与e-NIP-SPCE相比，e-MIP-SPCE的电化学性能显示在水介质中存在BPA时具有很高的灵敏度，检测限（LOD）为0.06 nM。用e-MIP-SPCE还观察到了对卡马西平和酮洛芬的选择性。然后将e-MIP（和e-NIP）微珠掺入石墨-羟乙基纤维素复合浆料中以制备SPCE。与e-NIP-SPCE相比，e-MIP-SPCE的电化学性能显示在水介质中存在BPA时具有很高的灵敏度，检测限（LOD）为0.06 nM。用e-MIP-SPCE还观察到了对卡马西平和酮洛芬的选择性。