The stability and bioavailability of acteoside were improved by encapsulating it with liposomes and chitosan. The liposomes were characterized through transmission electron microscopy, differential scanning calorimetry and Fourier transform infrared spectroscopy, and their particle size, zeta potential, encapsulation efficiency (EE), in vitro release, storage stability and oral bioavailability were tested. Results showed that the particles were nanosized and spherical. The average diameter, zeta potential, EE and relative bioavailability (F_rel) of the acteoside liposome (Ac-Lip) were 78.49 ± 1.44 nm, −4.93 ± 0.79 mV, 81.06 ± 3.48% and 217.62%, respectively. These parameters increased to 92.77 ± 2.99 nm, +19.65 ± 0.90 mV, 88.10 ± 5.36% and 442.84%, respectively, after the surface of Ac-Lip was coated with 2 mg/mL of chitosan (CS-Ac-Lip). In contrast to Ac-Lip, the CS-Ac-Lip showed a reduced in vivo release rate and enhanced storage stability. The chitosan coating increased the diameter, zeta potential, EE, in vivo release time, stability and bioavailability of the Ac-Lip, and the chitosan–liposome is a promising delivery system for transporting acteoside or other bioactive components.

通过用脂质体和壳聚糖包封，可以提高阿糖苷的稳定性和生物利用度。通过透射电子显微镜，差示扫描量热法和傅里叶变换红外光谱对脂质体进行了表征，并测试了它们的粒径，ζ电势，包封效率（EE），体外释放，储存稳定性和口服生物利用度。结果显示该颗粒是纳米尺寸的和球形的。平均直径，ζ电势，EE和相对生物利用度（F _rel核糖苷脂脂质体（Ac-Lip）的）分别为78.49±1.44 nm，-4.93±0.79 mV，81.06±3.48％和217.62％。在Ac-Lip的表面涂有2 mg / mL的脱乙酰壳多糖（CS-Ac-Lip）后，这些参数分别增加到92.77±2.99 nm，+ 19.65±0.90 mV，88.10±5.36％和442.84％。与Ac-Lip相比，CS-Ac-Lip显示出降低的体内释放速率和增强的储存稳定性。壳聚糖涂层增加了Ac-Lip的直径，ζ电位，EE，体内释放时间，稳定性和生物利用度，并且壳聚糖脂质体是一种有希望的传输系统，用于运输糖苷或其他生物活性成分。