To develop and validate numerical models of the laser in situ keratomileusis (LASIK) procedure through considering its effect on corneal biomechanical behavior. 3D finite element models of the human eye were developed to simulate LASIK. The models’ predictions of post-operative corneal elevation, corneal refractive power with vector decomposition (M_-c-pos, J_0-c-pos, J_45-c-pos) and refractive error correction (M_-rec, J_0-rec, J_45-rec) were compared against clinical data obtained for 28 eyes of 28 patients. A parallel exercise was conducted to estimate the post-operative corneal shape using a shape subtraction method (SSM) – which does not consider the effects of LASIK on corneal mechanical behavior – and the results are compared with the finite element method (FEM). A significant decrease in elevation differences between FEM predictions and clinical data was found compared with the differences between SSM results and clinical data (p = 0.000). In addition, there were no significant differences in post-operative equivalent sperical corneal refractive power between FEM results and corresponding clinical data (M_-c-pos: p = 0.501), while SSM showed significant differences with clinical data (M_-c-pos: p = 0.000). Further, FEM achieved a predicted value of M_-c-pos within ± 1.00D accuracy in 100% of cases, compared with 57% achieved by the SSM. M_-rec predicted by FEM was not significantly different from clinical results (p = 0.085), while SSM overestimated it (p = 0.000). The match between LASIK numerical model predictions with clinical measurements improved significantly when the procedure's effect on corneal biomechanical behavior was considered. This outcome has important implications on efforts to develop planning tools for refractive surgery.

通过考虑其对角膜生物力学行为的影响，开发和验证激光原位角膜磨镶术（LASIK）程序的数值模型。开发了人眼的3D有限元模型来模拟LASIK。该模型对术后角膜抬高，具有矢量分解功能的角膜屈光力（M _-c-pos，J _0-c-pos，J _45-c-pos）和屈光不正校正（M _-rec，J _0-记录，J _45-rec）与28例患者的28眼获得的临床数据进行了比较。进行了平行运动，使用形状减法（SSM）估计了术后角膜的形状-该方法未考虑LASIK对角膜力学行为的影响-并将结果与​​有限元方法（FEM）进行了比较。与SSM结果和临床数据之间的差异相比，FEM预测与临床数据之间的高度差异显着降低（p = 0.000）。此外，FEM结果与相应的临床数据之间的等效精囊角膜屈光力无显着差异（M _-c-pos：p = 0.501），而SSM与临床数据（M _-c-pos）有显着差异：p = 0.000）。此外，在100％的情况下，FEM达到的M _-c-pos预测值在±1.00D精度内，而SSM达到了57％。FEM预测的M _-rec与临床结果无显着差异（p = 0.085），而SSM高估了它（p = 0.000）。当考虑该手术对角膜生物力学行为的影响时，LASIK数值模型预测值与临床测量值之间的匹配度显着提高。这一结果对开发屈光手术计划工具的努力具有重要意义。