Personalized and regenerative medicine is an emerging therapeutic strategy that is based on cell biology and biomedical engineering used to develop biological substitutes to maintain normal function or restore damaged tissues and organs.

The secretory capacities of different cell types are now explored as such possible therapeutic regenerative agents in a variety of diseases. A secretome can comprise chemokines, cytokines, growth factors, but also extracellular matrix components, microvesicles and exosomes as well as genetic material and may differ depending on the tissue and the stimulus applied to the cell. With regard to clinical applications, the secretome of mesenchymal stem cells (MSC) is currently the most widely explored. However, other cell types such as pericytes may have similar properties as MSC and the potential therapeutic possibilities of these cells are only just beginning to emerge.

In this review, we will summarize the currently available data describing the secretome of pericytes and its potential implications for tissue regeneration, whereby we especially focus on brain pericytes as potential new target cell for neuroregeneration and brain repair.

个性化和再生医学是一种新兴的治疗策略，其基于细胞生物学和生物医学工程技术，用于开发生物替代品以维持正常功能或恢复受损的组织和器官。

现在已经探索了不同细胞类型的分泌能力，作为多种疾病中可能的治疗性再生剂。分泌组可以包含趋化因子，细胞因子，生长因子，还可以包含细胞外基质成分，微泡和外泌体以及遗传物质，并且可能取决于组织和对细胞施加的刺激而有所不同。关于临床应用，间充质干细胞（MSC）的分泌组是目前研究最广泛的。但是，其他类型的细胞（如周细胞）可能具有与MSC类似的特性，这些细胞的潜在治疗可能性才刚刚开始出现。

在这篇综述中，我们将总结描述周细胞分泌物组及其对组织再生的潜在影响的当前可用数据，其中，我们特别关注脑周细胞，作为神经再生和脑修复的潜在新靶细胞。