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The effect of oxysterols on nerve impulses
Biochimie ( IF 3.9 ) Pub Date : 2018-04-21
Maryem Bezine, Amira Namsi, Randa Sghaier, Rym Ben Khalifa, Haithem Hamdouni, Fatiha Brahmi, Iham Badreddine, Wafa Mihoubi, Thomas Nury, Anne Vejux, Amira Zarrouk, Jérôme de Sèze, Thibault Moreau, Boubker Nasser, Gérard Lizard

The propagation of nerve impulses in myelinated nerve fibers depends on a number of factors involving the myelin and neural axons. In several neurodegenerative diseases, nerve impulses can be affected by the structural and biochemical characteristics of the myelin sheath and the activity of ion channels located in the nodes of Ranvier. Though it is generally accepted that lipid disorders are involved in the development of neurodegenerative diseases, little is known about their impact on nerve impulses. Cholesterol oxide derivatives (also called oxysterols), which are either formed enzymatically or as a result of cholesterol auto-oxidation or both, are often found in abnormal levels in the brain and body fluids of patients with neurodegenerative diseases. This leads to the question of whether these molecules, which can accumulate in the plasma membrane and influence its structure and functions (fluidity, membrane proteins activities, signaling pathways), can have an impact on nerve impulses. It is currently thought that the ability of oxysterols to modulate nerve impulses could be explained by their influence on the characteristics and production of myelin as well as the functionality of Na+ and K+ channels.



中文翻译:

氧固醇对神经冲动的影响

神经冲动在有髓神经纤维中的传播取决于许多涉及髓鞘和神经轴突的因素。在几种神经退行性疾病中,髓鞘的结构和生化特性以及位于Ranvier淋巴结中的离子通道的活性会影响神经冲动。尽管人们普遍认为脂质紊乱与神经退行性疾病的发展有关,但对脂质紊乱对神经冲动的影响知之甚少。胆固醇氧化衍生物(也称为氧固醇),是通过酶促作用或胆固醇自身氧化作用或两者共同作用而形成的,通常在神经退行性疾病患者的大脑和体液中含量异常。这就引出了一个问题,这些分子是否 它可以在质膜中积聚并影响其结构和功能(流动性,膜蛋白活性,信号传导途径),会对神经冲动产生影响。目前认为,氧固醇调节神经冲动的能力可以通过其对髓鞘的特征和产生以及Na的功能性的影响来解释。+和K +频道。

更新日期:2018-04-25
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