Tetrabromobisphenol A (TBBPA) is one of the world's most widely used brominated flame retardants (BFRs) and considered as persistent halogenated contaminant. E-wastes contain a range of toxic chemicals, including BFRs and heavy metals, exerting adverse impacts to human health and environment. Nevertheless, comprehensive evaluation on combined toxicity of these co-existing pollutants is limited. This study conducted a subchronic effects of cadmium and TBBPA on the development and antioxidative defense system as well as thyroid functions in female rats through single and combined exposure at environmentally relevant doses for a 20-day consecutive administration. Body indexes, histopathology, redox status, and thyroid hormones levels were assessed. Slower body weight gains and reduced ovary weight (20.8% and 32.4% for combined and single-Cd exposures, respectively) were observed with significant variation from controls in high dose treatments. Co-exposure resulted in a slight enhancement in TSH levels compared to control (by 7.6% for high dose) without significance. TBBPA-Cd interactions are involved in the changes of kidney weight as well as the induction of SOD activities and MDA levels. The disturbances in the redox status may be a result of an independent effect of Cd and/or TBBPA and also of their interaction. The results implied under these treatment, kidney was more sensitive with significant increased organ coefficient and alteration for antioxidative indices (increasing by 46% for SOD activity). This study represents the toxic effects of Cd and TBBPA co-exposure through oral administration in pubertal rats, which may provide useful information for health risk assessment for young exposed individuals.

四溴双酚A（TBBPA）是世界上使用最广泛的溴化阻燃剂（BFR）之一，被视为持久性卤化污染物。电子废物包含多种有毒化学物质，包括溴化阻燃剂和重金属，对人体健康和环境产生不利影响。然而，对这些共存污染物的综合毒性的综合评价是有限的。这项研究通过连续和连续20天以环境相关剂量单次或联合暴露对镉和TBBPA的亚慢性影响，对雌性大鼠的发育和抗氧化防御系统以及甲状腺功能产生了慢性影响。评估身体指标，组织病理学，氧化还原状态和甲状腺激素水平。较慢的体重增加和减少的卵巢重量（分别为20.8％和32。在高剂量治疗中，与对照组相比，分别达到4％和2％的镉暴露，与对照组相比有显着差异。与对照组相比，共同暴露导致TSH水平略有提高（高剂量时为7.6％），无显着性。TBBPA-Cd相互作用涉及肾脏重量的变化以及SOD活性和MDA水平的诱导。氧化还原状态的紊乱可能是Cd和/或TBBPA的独立作用及其相互作用的结果。这些治疗结果暗示，肾脏更敏感，器官系数显着增加，抗氧化指数发生改变（SOD活性增加46％）。这项研究代表了青春期大鼠口服Cd和TBBPA共同暴露的毒性作用，