The fungus Neonectria discophora SNB-CN63 has been isolated from the nest of the termite Nasutitermes corniger found in French Guiana. From the ethyl acetate extract of fungal culture, bioassay guided fractionation led to the isolation of fourteen ilicicolinic acids and ilicicolinal derivatives. Their structures were elucidated by analyses of 1D and 2D NMR and MS spectroscopic data. All metabolites were tested against several microbial pathogens and six displayed antimicrobial activities with MIC <16 μg/mL on T. rubrum, Staphylococcus aureus and methicillin-resistant S. aureus. Based on their structural similarities, a common biosynthetic pathway is proposed for all isolated metabolites.

中文翻译：

---

从法属圭亚那发现的白蚁 Nasutitermes corniger 的巢中分离出的真菌 Neonectria discophora SNB-CN63 的 Ilicicolinic 酸和 Ilicicolinal 衍生物显示出抗菌活性

真菌 Neonectria discophora SNB-CN63 已从法属圭亚那发现的白蚁 Nasutitermes Corniger 的巢穴中分离出来。从真菌培养物的乙酸乙酯提取物中，生物测定引导的分级分离导致了十四个 iliicicolinic 酸和 ilicicolinal 衍生物的分离。通过一维和二维核磁共振和质谱数据分析阐明了它们的结构。所有代谢物都针对几种微生物病原体进行了测试，其中六种表现出抗菌活性，对红色毛癣菌、金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌的 MIC <16 μg/mL。基于它们的结构相似性，提出了所有分离代谢物的共同生物合成途径。