The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, epoxidation, O-methylation, ring-expansion and methyl migration reactions were observed on the triterpenoid skeleton. As a result, eight metabolites were isolated and the structures of the previously undescribed compounds were established by 1-D, 2-D NMR and HR-MS analyses.

中文翻译：

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内生真菌链格孢1E1BL1对环黄柏醇的生物转化

黄芪属环黄柏醇（CCG）的微生物转化。研究了由黄芪中分离出的内生真菌链霉菌Eureka 1E1BL1衍生的皂苷元。在三萜骨架上观察到羟基化，氧化，环氧化，O-甲基化，扩环和甲基迁移反应。结果，分离出八种代谢物，并通过1-D，2-D NMR和HR-MS分析建立了先前未描述的化合物的结构。