A new process methodology to obtain enantiopure (S)-Ibuprofen has been designed. Starting from racemic Ibuprofen, co-crystallization with Levetiracetam is used as a resolution tool to obtain only the target enantiomer, (S)-Ibuprofen, in the solid state. The resulting mother liquor, enriched in (R)-Ibuprofen, is recovered and submitted to a racemization cycle, after which another co-crystallization step is introduced. Levetiracetam can be recovered from the co-crystal phase and reused, resulting in an economical use of the resolution agent. Overall, a novel approach to transform a racemic compound into enantiopure material has been developed.

中文翻译：

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启用对映体纯度：将消旋和双药物共晶体拆分相结合

设计了一种新的工艺方法来获得对映纯（S）-布洛芬。从外消旋布洛芬开始，与左乙拉西坦共结晶被用作拆分工具，仅获得固态的目标对映异构体（S）-布洛芬。回收富含（R）-布洛芬的所得母液并进行消旋化循环，此后引入另一共结晶步骤。左乙拉西坦可从共结晶相中回收并再利用，从而可经济地使用拆分剂。总的来说，已经开发了一种将外消旋化合物转变为对映体纯净材料的新颖方法。