Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar sites in non-Caucasian subjects with dark skin type is still controversial. Here, we tested the diabetic complication screening performance of a novel SAF measuring system in Asian type 2 diabetes mellitus (T2DM) subjects. A total of 166 Korean patients with T2DM were enrolled in this study and palmoplantar SAF was measured by a newly developed transmission-geometry noninvasive optical system. We found that transmitted SAF values of palmoplantar sites, 1st dorsal interossei muscles of the hand, in a complication group were significantly higher than in a non-complication group while no differences were observed between the two groups in reflected SAF of non-palmoplantar sites. The transmitted SAF values of palmoplantar sites were dramatically increased in subjects with multiple complications and were tightly correlated with the duration of microvascular complications. In conclusion, the SAF measurement in the palmoplantar sites with a non-invasive transmission-geometry optical system provided better microvascular complication screening performance compared to the SAF measurement of non-palmoplantar sites specifically in Asian T2DM subjects.

中文翻译：

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亚洲2型糖尿病患者的掌sites皮肤自发荧光与微血管并发症之间的关系。

皮肤自发荧光（SAF）已引起人们对无创高级糖基化终末产物评估及其与微血管并发症发展的直接相互作用的前景的广泛兴趣，但是现有的SAF在非足底非non足部位测量的临床应用深色皮肤的白种人受试者仍存在争议。在这里，我们在亚洲2型糖尿病（T2DM）受试者中测试了新型SAF测量系统的糖尿病并发症筛查性能。本研究共纳入166名韩国T2DM患者，并通过新开发的透射几何无创光学系统对掌plant SAF进行了测量。我们发现，掌plant部位，手的第一背骨间肌传递的SAF值，并发症组中的SAF显着高于非并发症组，而两组之间在非pal足部位的反射SAF中未观察到差异。在患有多种并发症的受试者中，掌plant部位的透射SAF值显着增加，并且与微血管并发症的持续时间密切相关。总之，与亚洲非2型糖尿病2型糖尿病患者的非掌plant部位的SAF测量相比，采用非侵入性透射几何光学系统的掌plant部位的SAF测量提供了更好的微血管并发症筛查性能。在患有多种并发症的受试者中，掌plant部位的透射SAF值显着增加，并且与微血管并发症的持续时间密切相关。总之，与亚洲非2型糖尿病2型糖尿病患者的非掌plant部位的SAF测量相比，采用非侵入性透射几何光学系统的掌plant部位的SAF测量提供了更好的微血管并发症筛查性能。在患有多种并发症的受试者中，掌plant部位的透射SAF值显着增加，并且与微血管并发症的持续时间密切相关。总之，与亚洲非2型糖尿病2型糖尿病患者的非掌plant部位的SAF测量相比，采用非侵入性透射几何光学系统的掌plant部位的SAF测量提供了更好的微血管并发症筛查性能。