In this work, a low-cost, scalable and highly repeatable approach was developed to prepare polystyrene films with three-dimensional nanopyramids on the surface. The nanopyramids have a tunable aspect ratio and more importantly, their anti-bacterial performance has been systematically studied. The effectiveness of the nanopyramids on E. coli growth inhibition and the role of the nanostructure aspect ratio were carefully studied through scanning electron microscopy and confocal laser scanning microscopy. The results showed an excellent antibacterial performance with more than 90% reduction in the E. coli population in all nanopyramid samples after a 168 h prolonged incubation time. The nanopyramid film developed here can be used for clinical and commercial applications to prevent the growth of pathogenic bacteria on various surfaces.

中文翻译：

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用于临床的低成本，灵活，无消毒剂和规则阵列的三维纳米金字塔抗菌膜†

在这项工作中，开发了一种低成本，可扩展且高度可重复的方法来制备表面具有三维纳米金字塔的聚苯乙烯薄膜。纳米金字塔具有可调节的长径比，更重要的是，已经对其抗菌性能进行了系统的研究。通过扫描电子显微镜和共聚焦激光扫描显微镜仔细研究了纳米金字塔对大肠杆菌生长的抑制作用和纳米结构纵横比的作用。结果显示出优异的抗菌性能，大肠杆菌含量降低了90％以上经过168小时的温育时间后，所有纳米金字塔样品中的细菌数量都会增加。此处开发的纳米金字塔膜可用于临床和商业应用，以防止病原菌在各种表面上生长。