当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Transition‐Metal‐Free Decarboxylative Propargylic Substitution/Cyclization with either Azolium Enolates or Acyl Anions
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2018-04-19 , DOI: 10.1002/anie.201801340
Shenci Lu 1 , Jun-Yang Ong 1, 2 , Si Bei Poh 1 , Terence Tsang 1 , Yu Zhao 1, 2
Affiliation  

Presented herein is an unprecedented transition‐metal‐free propargylic substitution reaction with either azolium enolates or acyl anions, which are generated from aldehydes under N‐heterocyclic carbene catalysis. This new catalytic activation operates on readily available cyclic propargylic carbamates through decarboxylation, and generates reactive allene intermediates that can undergo divergent cyclization pathways to deliver skeletally diverse polycyclic compounds with high levels of efficiency and excellent enantioselectivities.

中文翻译:

偶氮烯醇盐或酰基阴离子的无过渡金属脱羧丙炔基取代/环化

本文介绍了一种空前的无过渡金属的炔丙基取代反应,它与氮杂环卡宾催化下的醛类生成的烯醇氮或酰基阴离子。这种新的催化活化作用是通过脱羧作用在易于获得的环状丙炔基氨基甲酸酯上,并生成反应性丙二烯中间体,该中间体可以经历不同的环化途径,从而以高水平的效率和出色的对映选择性提供骨架多样的多环化合物。
更新日期:2018-04-19
down
wechat
bug