Stroke can lead to long-term neurological deficits. Adult neurogenesis, the continuous generation of newborn neurons in distinct regions of the brain throughout life, has been considered as one of the appoaches to restore the neurological function following ischemic stroke. However, ischemia-induced spontaneous neurogenesis is not suffcient, thus cell-based therapy, including infusing exogenous stem cells or stimulating endogenous stem cells to help repair of injured brain, has been studied in numerous animal experiments and some pilot clinical trials. While the effects of cell-based therapy on neurological function during recovery remains unproven in randomized controlled trials, pharmacological agents have been administrated to assist the cell-based therapy. In this review, we summarized the limitations of ischemia-induced neurogenesis and stem-cell transplantation, as well as the potential proneuroregenerative effects of drugs that may enhance efficacy of cell-based therapies. Specifically, we discussed drugs that enhance proliferation, migration, differentiation, survival and function connectivity of newborn neurons, which may restore neurobehavioral function and improve outcomes in stroke patients.

中文翻译：

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缺血性中风损伤后促进基于干细胞治疗的药理学方法。

中风可导致长期的神经功能缺损。成人神经发生是一生中在大脑各个区域连续产生新生神经元的神经元，已被认为是在缺血性中风后恢复神经功能的一种方法。然而，缺血诱导的自发性神经发生不足​​，因此在许多动物实验和一些试验性临床试验中已经研究了基于细胞的疗法，包括注入外源性干细胞或刺激内源性干细胞以帮助修复受损的大脑。虽然在随机对照试验中尚未证实基于细胞的疗法对恢复过程中神经功能的影响，但已施用了药物来辅助基于细胞的疗法。在这篇评论中，我们总结了局部缺血诱导的神经发生和干细胞移植的局限性，以及可能增强基于细胞的疗法疗效的药物的潜在神经再生作用。具体来说，我们讨论了可增强新生儿神经元增殖，迁移，分化，存活和功能连接的药物，这些药物可恢复中风患者的神经行为功能并改善结局。