New experiments for undergraduate students are needed to stimulate experiential learning in the laboratory while providing valuable training for future career development. Iodine deficiency remains a major public health concern that is monitored by measuring the median urinary iodide concentration of a population. In this context, we have introduced a kinetic spectrophotometric experiment based on the classic Sandell–Kolthoff reaction for second-year undergraduate students in analytical chemistry. This two-day laboratory experiment incorporates principles of quantitative chemical analysis, redox chemistry, reaction kinetics, optical spectroscopy, sample pretreatment, external calibration, method validation, statistical analysis, and quality assurance. Additionally, students gain real-world experience of implementation of a reliable analytical method used in global health initiatives to combat iodine deficiency, including participation in a round-robin study with the CDC. This colorimetric assay is widely used for continuous monitoring of mandatory iodized table salt programs to prevent the risk of iodine deficiency disorders, including developmental delays and intellectual impairment in children.

中文翻译：

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动力学分光光度法测量碘营养：分析化学对人口健康的综合实验室实验

需要针对本科生的新实验，以激发实验室的经验学习，同时为未来的职业发展提供有价值的培训。碘缺乏症仍然是主要的公共卫生问题，可以通过测量人群中碘尿酸中位数来监测。在这种情况下，我们针对经典的桑德尔-科尔索夫反应，针对分析化学二年级学生推出了动力学分光光度法实验。这个为期两天的实验室实验结合了定量化学分析，氧化还原化学，反应动力学，光谱学，样品预处理，外部校准，方法验证，统计分析和质量保证的原理。此外，学生将获得实施可靠的分析方法的真实经验，该方法可用于全球卫生计划以应对碘缺乏症，包括参与CDC的循环研究。这种比色测定法广泛用于连续监测强制性加碘食盐程序，以防止发生碘缺乏症（包括儿童发育迟缓和智力障碍）的风险。