A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF₃SO₃H and a fluorinated chiral diamine Ru(II) complex in aqueous CF₃CH₂OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.

中文翻译：

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CF3SO3H/钌串联催化从炔烃一锅法合成手性醇†

_{描述了通过在 CF 3} CH ₂ OH水溶液中结合 CF ₃ SO ₃ H 和氟化手性二胺 Ru( II )配合物，从现成的炔烃通过串联催化的实用一锅法合成手性醇。非常有趣的是，氟化催化剂和溶剂的组合对反应性和对映选择性表现出积极的氟效应。在简单温和的条件下，以高收率和优异的立体选择性获得了一系列具有广泛官能团耐受性的手性醇。