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Atom‐Economic Silver‐Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2018-04-19 , DOI: 10.1002/anie.201801363
Hong-Wen Liang 1 , Zhen Yang 1 , Kun Jiang 1 , Ying Ye 1 , Ye Wei 1
Affiliation  

An unprecedented silver‐catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom‐economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late‐stage modification of a few biologically active molecules.

中文翻译:

异氰酸酯基与环肟的原子经济银催化双官能度:嘧啶二酮

描述了前所未有的银催化的异氰酸酯基与环肟的双官能化。这种方法可以高效,原子经济地组装大量结构新颖,有趣的嘧啶二酮,并具有一定的功能范围。所得产物可以容易地转化成一些有用的化合物。此外,该方法还可用于一些生物活性分子的后期修饰。
更新日期:2018-04-19
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