Nine dimeric acylphloroglucinols, including the new hyperjaponicols A–D (1–4), were isolated from the whole plant of Hypericum japonicum. The new structures were determined by the interpretation of NMR and MS data, and the relative configuration of the known compound, sarothralen C (5), was reassigned via NMR spectroscopic analysis and single-crystal X-ray diffraction data. The inhibitory activities of the isolates against four bacterial strains were evaluated, and compounds 1–4, 6, and 7 exhibited significant antibacterial activity with MIC values of 0.8–3.4 μM. In addition, compound 3 showed moderate lipase inhibitory activity (IC₅₀ 8.3 μM).

中文翻译：

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日本贯叶连翘的抗菌二聚酰基间苯二酚

九个二聚体acylphloroglucinols，包括新的hyperjaponicols A-d（1 - 4）中，从全植物中分离田基。通过解释NMR和MS数据确定了新的结构，并通过NMR光谱分析和单晶X射线衍射数据重新分配了已知化合物sarothralen C（5）的相对构型。针对4个细菌菌株分离物的抑制活性进行了评价，和化合物1 - 4，6，和7显示出显著的抗菌活性与0.8-3.4μM的MIC值。另外，化合物3表现出中等的脂肪酶抑制活性（IC ₅₀ 8.3μM）。