A telescoped multistep process to provide the continuous delivery of 16-dehydropregnenolone acetate (16-DPA) from diosgenin is described. The method was evaluated through batch screenings that helped to identify critical bottlenecks and flowability, and the best conditions were optimized in flow systems before the individual steps were telescoped together into a single integrated flow process. Further highlights of our approach include the use of efficient in-line extraction operations and reaction monitoring, the avoidance of time-consuming purifications between steps, and improvement of efficiency and safety standards.

中文翻译：

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连续流合成16-脱氢孕烯醇酮乙酸酯，天然类固醇和药物的关键合成子

描述了一种伸缩的多步骤方法，用于从薯os皂苷元连续递送乙酸16-脱氢孕烯醇酮（16-DPA）。通过分批筛选评估了该方法，该筛选有助于确定关键瓶颈和流动性，并且在将各个步骤一起伸缩到单个集成流动过程之前，在流动系统中优化了最佳条件。我们方法的进一步亮点包括使用高效的在线萃取操作和反应监控，避免了步骤之间的耗时纯化以及提高效率和安全标准。