An efficient copper‐catalyzed ethoxycarbonyldifluoromethylation of indoles and pyrroles with commercially available BrCF₂CO₂Et is reported. The developed protocol allows the site‐selective introduction of the CF₂CO₂Et moiety at the C2‐position of N‐heteroarenes with the assistance of a pyrimidyl group using CuI as the catalyst and 4,7‐diphenyl‐1,10‐phenanthroline as the ligand. This procedure is scalable and tolerates various important functional groups.

中文翻译：

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铜催化的吲哚和吡咯乙氧基羰基二氟甲基化

据报道，使用市售的BrCF ₂ CO ₂ Et可有效地进行吲哚和吡咯的铜催化乙氧基羰基二氟甲基化。已开发的方案允许在嘧啶基的辅助下，使用CuI作为催化剂和4,7-二苯基-1,10-菲咯啉在N-杂芳烃的C2位上选择性引入CF ₂ CO ₂ Et部分作为配体。此过程是可伸缩的，并且可以容忍各种重要的功能组。