Atrial fibrillation (AF) is the most common cardiac arrhythmia that occurs because of several different risk factors, e.g., valvular heart disease, coronary artery disease, age ≥75 years, hypertension and diabetes mellitus. One key risk factor that results in AF, is oxidative stress. Evidence suggests that there is a correlation between oxidative processes and the genesis of AF. Oxidative stress occurs when the generation of reactive oxygen species (ROS) increase due to excessive activity of enzymes including NADPH oxidase (NOX) and xanthine oxidase; or its degradation decrease by dysfunctional antioxidant enzyme systems, such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx). Afterwards, elevated ROS may shift ion channel activity to increase AF susceptibility.

中文翻译：

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应用天然化合物治疗房颤更有效；作为NADPH氧化酶和离子通道抑制剂

心房颤动（AF）是最常见的心律不齐，其发生是由于多种不同的危险因素，例如瓣膜性心脏病，冠状动脉疾病，年龄≥75岁，高血压和糖尿病。导致房颤的一个关键危险因素是氧化应激。有证据表明，氧化过程与房颤的发生之间存在相关性。当由于包括NADPH氧化酶（NOX）和黄嘌呤氧化酶在内的酶的过度活性而增加活性氧（ROS）的产生时，就会发生氧化应激。或由于功能失调的抗氧化酶系统（例如超氧化物歧化酶（SOD），过氧化氢酶和谷胱甘肽过氧化物酶（GPx））而使其降解降低。之后，升高的ROS可能会改变离子通道活性，从而增加AF敏感性。