A novel heteroannulation reaction between α‐amino imides and in situ generated arynes has been developed for the synthesis of 2,2‐disubstituted indolin‐3‐ones. An enantioselective total synthesis of the marine alkaloid (+)‐hinckdentine A was subsequently accomplished using this reaction as a key step. A catalytic enantioselective Michael addition of an α‐aryl‐α‐isocyanoacetate to phenyl vinyl selenone was employed for the construction of the enantioenriched α‐quaternary α‐amino ester.

中文翻译：

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带有α-氨基酰亚胺的芳烃的杂环化：2,2-二取代的吲哚-3-酮的合成及其对（+）-欣克汀丁A的对映选择性合成

已经开发了一种α-氨基酰亚胺和原位生成的芳烃之间的新型异环化反应，用于合成2,2-二取代的吲哚-3-酮。随后使用该反应作为关键步骤，完成了海洋生物碱（+）-hinckdentine A的对映选择性全合成。将α-芳基-α-异氰基乙酸酯的对映体选择性催化迈克尔加成到苯基乙烯基硒酮中，用于构建对映体富集的α-季铵α-氨基酯。