The asymmetric synthesis of 3‐substituted oxindoles is a topic of considerable importance because these functionalized heterocycles are found in many natural products and drugs. In the last decade, significant advances have been made towards the asymmetric synthesis of 3‐heteroatom‐substituted oxindoles as a result of major improvements in asymmetric organocatalysis. This review will focus on the different types of asymmetric electrophilic organocatalyzed reactions, including the amination, halogenation, hydroxylation, and sulfenylation of oxindoles to form their enantioenriched 3‐heterosubstituted derivatives.

中文翻译：

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吲哚的不对称有机催化亲电杂官能化

3-取代的羟吲哚的不对称合成是一个相当重要的话题，因为这些官能化的杂环存在于许多天然产物和药物中。在过去的十年中，由于不对称有机催化的重大改进，在3杂原子取代的羟吲哚的不对称合成方面取得了重大进展。这篇综述将集中在不对称亲电有机催化反应的不同类型上，包括羟吲哚的胺化，卤化，羟基化和亚磺酰基化，以形成其对映体富集的3-杂取代衍生物。