Metabolite amyloid-like fibrils interact with model membranes†,Chemical Communications

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Metabolite amyloid-like fibrils interact with model membranes†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-04-17 00:00:00 , DOI: 10.1039/c8cc01423j
Shira Shaham-Niv _{1,

2,

3,

4,

5} , Pavel Rehak _{6,

7,

8,

9} , Dor Zaguri _{1,

2,

3,

4,

5} , Sofiya Kolusheva _{5,

10,

11,

12} , Petr Král _{6,

7,

8,

9,

13} , Ehud Gazit _{1,

2,

3,

4,

5}

Affiliation

Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

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