The incorporation of C‐glycosides in drug design has become a routine practice for medicinal chemists. These naturally occurring building blocks exhibit attractive pharmaceutical profiles, and have become an important target of synthetic efforts in recent decades.¹ Described herein is a practical, scalable, and versatile route for the synthesis of non‐anomeric and unexploited C‐acyl glycosides through a Ni/photoredox dual catalytic system. By utilizing an organic photocatalyst, a range of glycosyl‐based radicals are generated and efficiently coupled with highly functionalized carboxylic acids at room temperature. Distinctive features of this transformation include its mild conditions, impressive compatibility with a wide array of functional groups, and most significantly, preservation of the anomeric carbon: a handle for further, late‐stage derivatization.

中文翻译：

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Ni/光氧化还原双催化合成反C-酰基糖苷

在药物设计中加入C-糖苷已成为药物化学家的常规做法。这些天然存在的结构单元表现出有吸引力的药物特性，并已成为近几十年来合成工作的重要目标。¹本文描述的是一种通过 Ni/光氧化还原双催化系统合成非异头和未开发的C-酰基糖苷的实用、可扩展且通用的路线。通过利用有机光催化剂，可以产生一系列糖基自由基，并在室温下与高度功能化的羧酸有效偶联。这种转化的显着特征包括其温和的条件、与多种官能团的令人印象深刻的相容性，以及最重要的是，保留了异头碳：为进一步的后期衍生化提供了手段。