Published as part of the Special Topic Modern Radical Methods and their Strategic Applications in Synthesis

Abstract

An iron-catalyzed carboiodination of alkynes with alkyl iodides­ at room temperature was developed. This method could provide synthetically useful vinyl iodides with general alkyl chains, fluoroalkyl group, ester, and cyano group. Conjugated alkynes or unconjugated alkynes were both suitable for this transformation. A radical pathway was proposed for the mechanism and acetyl tert-butyl peroxide was selected as the radical initiator. Alkenes could also be applied to this chemistry and produce more complex alkyl iodides.

An iron-catalyzed carboiodination of alkynes with alkyl iodides­ at room temperature was developed. This method could provide synthetically useful vinyl iodides with general alkyl chains, fluoroalkyl group, ester, and cyano group. Conjugated alkynes or unconjugated alkynes were both suitable for this transformation. A radical pathway was proposed for the mechanism and acetyl tert-butyl peroxide was selected as the radical initiator. Alkenes could also be applied to this chemistry and produce more complex alkyl iodides.

中文翻译：

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铁催化炔烃的碳碘化

作为特别主题“现代自由基方法及其在合成中的战略应用”的一部分发布

抽象的

开发了在室温下炔烃与烷基碘的铁催化碳碘化反应。该方法可提供具有一般烷基链，氟代烷基，酯和氰基的合成上有用的乙烯基碘。共轭炔烃或非共轭炔烃均适用于该转化。为该机理提出了自由基途径，并选择了乙酰基叔丁基过氧化物作为自由基引发剂。烯烃也可用于该化学方法并产生更复杂的烷基碘。

开发了在室温下炔烃与烷基碘的铁催化碳碘化反应。该方法可提供具有一般烷基链，氟代烷基，酯和氰基的合成上有用的乙烯基碘。共轭炔烃或非共轭炔烃均适用于该转化。为该机理提出了自由基途径，并选择了乙酰基叔丁基过氧化物作为自由基引发剂。烯烃也可用于该化学方法并产生更复杂的烷基碘。