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Visible light active nanofibrous membrane for antibacterial wound dressing†
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2018-04-13 00:00:00 , DOI: 10.1039/c8nh00021b
Shuai Jiang 1, 2, 3 , Beatriz Chiyin Ma 1, 2, 3 , Wei Huang 1, 2, 3 , Anke Kaltbeitzel 1, 2, 3 , Gönül Kizisavas 1, 2, 3 , Daniel Crespy 1, 2, 3, 4, 5 , Kai A. I. Zhang 1, 2, 3 , Katharina Landfester 1, 2, 3
Affiliation  

Chronic wound infections, especially due to the emergence of multidrug resistance in bacteria, require the urgent development of alternative antibacterial therapies. Here, we developed a new class of hydrogel nanofibrous membranes that show visible light-induced disinfection. The presented photocatalytic disinfection is based on the generation of reactive singlet oxygen from a conjugated microporous polymer upon visible light irradiation. Therefore, sustained protection of the wound area can be provided in the presence of visible light. Fabrication of the photoactive wound dressing consists of first synthesizing photoactive conjugated microporous polymer nanoparticles by miniemulsion polymerization and subsequently embedding the nanoparticles in polyvinyl alcohol hydrogel nanofibers by colloid-electrospinning. The fibers were then crosslinked in glutaraldehyde/HCl vapor to be water-insoluble. This nanoparticle-in-nanofiber structure allows for a flexible combination of the properties of the nanoparticles and supporting nanofibers. The disinfecting properties of the membranes were evaluated with the inactivation of Escherichia coli K-12 and Bacillus subtilis as model systems of Gram-negative and Gram-positive bacteria, as well as the inhibition of biofilm growth under irradiation of visible light. Cytotoxicity tests on fibroblast cells revealed a high cytocompatibility of the membranes. Furthermore, the good mechanical properties of the membranes allow for their facile removal after use and prevent the leakage of the embedded nanoparticles into the wound, making the photoactive hydrogel membranes a promising candidate for active wound dressing materials.

中文翻译:

可见光活性纳米纤维膜,用于抗菌伤口敷料

慢性伤口感染,特别是由于细菌中出现多药耐药性,需要紧急开发其他抗菌疗法。在这里,我们开发了一种新型的水凝胶纳米纤维膜,该膜表现出可见光诱导的消毒作用。提出的光催化消毒是基于可见光辐照下从共轭微孔聚合物中生成反应性单线态氧。因此,在可见光的存在下可以提供对伤口区域的持续保护。光敏伤口敷料的制造包括首先通过细乳液聚合合成光敏共轭微孔聚合物纳米颗粒,然后通过胶体电纺丝将纳米颗粒包埋在聚乙烯醇水凝胶纳米纤维中。然后将纤维在戊二醛/ HCl蒸气中交联为不溶于水的。这种纳米纤维中的纳米颗粒结构允许纳米颗粒和支撑纳米纤维的性质的灵活组合。用灭活的方式评估膜的消毒性能。大肠杆菌K-12和枯草芽孢杆菌作为革兰氏阴性和革兰氏阳性细菌的模型系统,以及在可见光照射下对生物膜生长的抑制作用。对成纤维细胞的细胞毒性测试显示了膜的高细胞相容性。此外,膜的良好机械性能允许在使用后将其轻松去除,并防止嵌入的纳米颗粒泄漏到伤口中,从而使光活性水凝胶膜成为活性伤口敷料材料的有希望的候选者。
更新日期:2018-04-13
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