The objective of this study is to evaluate the effects of a diet with goat milk fat supplemented with physical training on markers of oxidative stress in the brain and anxiety behavior in rats. Adult male rats were randomly divided into six groups (n = 10 per group): control sedentary (CON) and exercised (CON-EX) groups, goat milk fat sedentary (GM) and exercised (GM-EX) groups, goat milk fat enriched with CLA sedentary (GM-CLA) and exercised (GM-CLA-EX) groups. The exercised groups were submitted to treadmill running during four weeks. Anxiety parameters were evaluated with the open field (OF) and elevated plus maze (EPM) tests. Malondialdehyde (MDA) and glutathione (GSH) levels were measured in the brain. Compared to the CON and GM groups, the GM-CLA group (p < 0.05), in which the animals were treated with goat milk fat with an increased CLA content, showed higher rearing. All exercised animals presented an increase in grooming when compared to sedentary animals. The number of entries in the open arms and time spent in the open arms was higher in sedentary groups (p < 0.05). MDA levels in the brain were lower in the GM group when compared to those in the CON group (p < 0.05). MDA increased in exercised animals (p < 0.05). GM and GM-CLA groups showed a significant elevation in the GSH levels in the brain. Goat milk fat, however, showed a potential effect on the reduction of oxidative stress, which was associated with a reduction in anxiety behavior. However, this beneficial effect was reversed when exercise was involved.

中文翻译：

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补充运动的山羊奶饮食对成年大鼠大脑焦虑和氧化应激的影响†

这项研究的目的是评估饮食加山羊奶补充体育锻炼对大脑中氧化应激和焦虑行为指标的影响。将成年雄性大鼠随机分为六组（每组n = 10）：对照久坐（CON）和运动（CON-EX）组，久坐的山羊奶脂肪（GM）和运动（GM-EX），山羊奶脂肪丰富了CLA久坐（GM-CLA）和运动（GM-CLA-EX）组。运动组在四个星期内接受跑步机训练。焦虑参数通过开放视野（OF）和高架迷宫（EPM）测试进行评估。在大脑中测量丙二醛（MDA）和谷胱甘肽（GSH）的水平。与CON和GM组相比，GM-CLA组（p<0.05）（其中动物用CLA含量增加的山羊奶脂肪处理）显示出更高的饲养。与久坐的动物相比，所有运动过的动物的修饰性都有所提高。在久坐的人群中，张开双臂的次数和张开双臂的时间更长（p <0.05）。与CON组相比，GM组的大脑中MDA水平较低（p <0.05）。运动动物的MDA升高（p<0.05）。GM和GM-CLA组显示大脑中GSH水平明显升高。然而，山羊乳脂肪显示出对减少氧化应激的潜在作用，这与焦虑行为的减少有关。但是，当进行运动时，这种有益的作用就被逆转了。