Crohn's Disease (CD) and Ulcerative Colitis (UC) result from an overreaction of the bowel to multifactorial stimuli leading to discomfort, pain, and it is associated with high morbidity and lethality. The medications commonly used are expensive and associated with multiple side effects. Curcuma longa exerts anti-inflammatory and antioxidant actions and has shown positive effects on CD and UC treatment, possibly due to the presence of curcuminoids. The objective of this review was to evaluate the role of curcuminoids in the treatment of IBD. A search for articles associating curcuminoids and CD and UC was performed using MEDLINE–PubMed. It has been found that curcumin can reduce oxidative stress and inhibit the migration of neutrophils and inducible nitric oxide synthase in the intestine. It may also improve micro and macroscopic lesions, prevent apoptosis of intestinal cells and also induce the restoration of the mitogen-activated protein kinase immune reaction. As the incidence of CD and UC is growing in many populations, there is an urgency to find an appropriate and accessible therapeutic approach to improve quality of life of patients. The use of curcumin is cheap, efficient and associated with no side effects, and may become an alternative to the IBD treatment.

中文翻译：

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从姜黄色素姜黄：克罗恩病和溃疡性结肠炎的治疗新辅料？

克罗恩病（CD）和溃疡性结肠炎（UC）是由于肠对多因素刺激的过度反应导致不适，疼痛而引起的，与高发病率和致死率相关。常用的药物价格昂贵，并伴有多种副作用。姜黄素发挥抗炎和抗氧化作用，并且对CD和UC治疗显示出积极作用，这可能是由于存在姜黄素所致。这篇综述的目的是评估姜黄素在IBD治疗中的作用。使用MEDLINE–PubMed搜索与姜黄素，CD和UC相关的文章。已经发现姜黄素可以减少氧化应激并抑制中性粒细胞和诱导型一氧化氮合酶在肠道中的迁移。它还可以改善微观和宏观病变，防止肠道细胞凋亡，并诱导有丝分裂原激活的蛋白激酶免疫反应的恢复。随着CD和UC的发病率在许多人群中不断增长，迫切需要找到一种合适且可及的治疗方法来改善患者的生活质量。姜黄素的使用便宜，有效并且没有副作用，并且可能成为IBD治疗的替代方法。