Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.

中文翻译：

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通过原位形成的丙二烯酸经酸促进的一锅合成呋喃和6-甲基吡嗪-2（1 H）-one衍生物

在酸性条件下，通过一锅中相应的丙二烯中间体由γ-炔基酮构建取代的呋喃。该方法还针对用于合成6-甲基吡嗪-2（1 H）-one衍生物的一系列Ugi反应产物进行了定制。当前的方法为这些化学支架的组合应用提供了显着的优势。