Diabetes affects millions of people worldwide and the number of diagnoses continues to climb annually. Though several effective medications and therapeutic methods have been developed to treat type 1 (T1DM) and type 2 (T2DM) diabetes mellitus, direct insulin injection remains the only effective treatment for insulin resistant (IR) diabetes patients. Here, we immobilize insulin in a crystalline mesoporous metal-organic framework (MOF), NU-1000, and obtain a high loading of ∼40 wt % in only 30 min. The acid-stable MOF capsules are found to effectively prevent insulin from degrading in the presence of stomach acid and the digestive enzyme, pepsin. Furthermore, the encapsulated insulin can be released from NU-1000 under simulated physiological conditions.

中文翻译：

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面向口服胰岛素递送的耐酸介孔金属-有机框架：蛋白质封装、保护和释放

糖尿病影响着全世界数百万人，并且诊断数量每年都在不断攀升。尽管已经开发了几种有效的药物和治疗方法来治疗 1 型 (T1DM) 和 2 型 (T2DM) 糖尿病，但直接注射胰岛素仍然是胰岛素抵抗 (IR) 糖尿病患者的唯一有效治疗方法。在这里，我们将胰岛素固定在结晶中孔金属有机骨架 (MOF) NU-1000 中，并在仅 30 分钟内获得了约 40 wt% 的高负载量。发现酸稳定的 MOF 胶囊可有效防止胰岛素在胃酸和消化酶胃蛋白酶的存在下降解。此外，在模拟生理条件下，包裹的胰岛素可以从 NU-1000 中释放出来。