An N-heterocyclic carbene-catalyzed annulation of ynals and amidines has been reported to construct pyrimidin-4-ones. The protocol features a broad substrate scope and mild conditions. Furthermore, an oxidative strategy to catalytically generate ynal-derived acyl azolium intermediates is discussed in this mechanistic study.

中文翻译：

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N-杂环卡宾催化的与的环合反应：获得1,2,6-三取代的嘧啶-4-酮†

据报道，N-杂环卡宾催化的芳基和am基环化反应可构建嘧啶-4-酮。该协议具有广泛的底物范围和温和的条件。此外，在该机理研究中还讨论了一种催化合成醛基酰基偶氮中间体的氧化策略。