Within the framework of a systems toxicology approach, the inhalation toxicity of aerosol from a novel tobacco-heating potentially modified risk tobacco product (MRTP), the carbon-heated tobacco product (CHTP) 1.2, was characterized and compared with that of mainstream smoke (CS) from the 3R4F reference cigarette in a 90-day nose-only rat inhalation study in general accordance with OECD TG 413. CHTP1.2 is a heat-not-burn product using a carbon heat source to produce an aerosol that contains nicotine and tobacco flavor. At equal or twice the nicotine concentration in the test atmospheres, inhalation of CHTP1.2 aerosol led to a significantly lower exposure to harmful constituents and induced less respiratory tract irritation, systemic, and pathological effects compared with CS. Nasal epithelial changes were less pronounced in the CHTP1.2- than in the CS-exposed groups and reverted in the nicotine concentration-matched group after a recovery period. Lung inflammation was minimal in the CHTP1.2-treated groups compared with the moderate extent seen in the 3R4F groups. Many other toxicological endpoints evaluated did not show CHTP1.2 aerosol exposure-related effects, and no effects not seen for 3R4F were observed. These observations were consistent with findings from previous studies in which rats were exposed to MRTP aerosols containing similar nicotine concentrations.

在系统毒理学方法的框架内，对来自新型烟草加热潜在风险烟草产品（MRTP），碳加热烟草产品（CHTP）1.2的气溶胶的吸入毒性进行了表征，并与主流烟气进行了比较（ CS）是根据OECD TG 413进行的为期90天的仅鼻子吸鼻的大鼠吸入研究中的3R4F参考香烟所产生的。CHTP1.2是一种不燃烧的产品，使用碳热源产生包含尼古丁和烟草味。与CS相比，在测试大气中尼古丁浓度等于或两倍时，吸入CHTP1.2气雾剂会导致有害成分的暴露显着降低，并引起较少的呼吸道刺激，全身和病理影响。鼻上皮变化在CHTP1中不太明显。恢复期后，CS暴露组比2-暴露于CS组，烟碱浓度匹配组恢复。与在3R4F组中观察到的中度程度相比，在CHTP1.2处理组中，肺部炎症最小。评估的许多其他毒理学终点未显示CHTP1.2气溶胶暴露相关的影响，也未观察到3R4F未见的影响。这些观察结果与以前的研究结果一致，在先前的研究中，大鼠暴露于含有相似烟碱浓度的MRTP气雾剂中。并且未观察到对于3R4F未见的作用。这些观察结果与以前的研究结果一致，在先前的研究中，大鼠暴露于含有相似烟碱浓度的MRTP气雾剂中。并且未观察到对于3R4F未见的作用。这些观察结果与以前的研究结果一致，在先前的研究中，大鼠暴露于含有相似烟碱浓度的MRTP气雾剂中。