Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation (“inflammaging”) and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and autoimmunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.

中文翻译：

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免疫衰老，表观遗传学和自身免疫

人和动物免疫系统的衰老的特征在于适应性免疫反应和先天性免疫反应均下降。矛盾的是，衰老还与慢性炎症（“发炎”）状态和发展自身免疫性疾病的可能性增加有关。由于环境因素，非分裂和分裂细胞（包括免疫细胞）的表观遗传变化导致了衰老状态和疾病的炎症和自身免疫。在这里，我们审查了涉及衰老的免疫衰老和自身免疫发展的表观遗传机制。