Although recent progress has been made in introducing an SCF₃ functionality into a variety of molecules, enantioselective trifluoromethylthiolation remains challenging, especially the α-trifluoromethylthiolation of carbonyl compounds. The present study describes a diastereo and enantioselective Cu-catalyzed tandem 1,4-addition/trifluoromethylthiolation of acyclic enones. The tandem reaction enables the asymmetric integration of the –SCF₃ group to carbonyl compounds, establishing chiral tertiary α-carbon centers and affording α-SCF₃-β-substituted carbonyl compounds in 50–92% yields with up to 20 : 1 dr and 96% ee.

中文翻译：

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通过非对映和对映选择性的Cu催化串联反应催化 羰基化合物的不对称三氟甲基硫醇化反应†

尽管在将SCF ₃官能团引入各种分子中已经取得了最新进展，但是对映选择性三氟甲基硫醇化仍然具有挑战性，尤其是羰基化合物的α-三氟甲基硫醇化。本研究描述了非环烯酮的非对映和对映选择性的Cu催化串联1,4-加成/三氟甲基硫醇化。的串联式反应使-SCF的不对称整合₃组的羰基化合物，在建立手性叔α碳中心和，得到α-SCF ₃ -β取代的羰基化合物中具有高达50〜92分％的收率，以20：1个的博士和96％ee。