A Cu-catalyzed tandem synthesis of azole-fused pyrimido[1,2-c]quinazolines and imidazo[1,2-c]quinazolines has been developed. The reaction is based on a C-N cross-coupling/C-H functionalization reaction of 2-(2-bromophenyl)-1,4,5,6-tetrahydropyrimidines with azoles. A variety of the desired polycyclic products were obtained in moderate to excellent yields.

中文翻译：

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铜催化的CN偶联/ CH官能化：串联的唑稠合喹唑啉衍生物

已开发出Cu催化串联合成吡咯并嘧啶并[1,2-c]喹唑啉和咪唑并[1,2-c]喹唑啉的方法。该反应基于2-（2-溴苯基）-1,4,5,6-四氢嘧啶与唑的CN交叉偶联/ CH官能化反应。以中等到优异的收率获得了各种所需的多环产品。