In this paper, we describe our efforts toward the asymmetric synthesis of Daphniphyllum alkaloid 21-deoxymacropodumine D which led to efficient preparation of a ABC tricyclic framework containing five consecutive stereocenters. This synthetic work features (1) utilization of an asymmetric conjugate addition to install the C5 all-carbon quaternary center, (2) an intramolecular aza-Michael addition followed by Pd-catalyzed α-alkenylation to build the bowl-shaped tricyclic core.

中文翻译：

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红水生生物碱21-脱氧-巨人草胺D中ABC三环核的不对称合成

在本文中，我们描述了我们对的不对称合成努力虎皮楠生物碱21 deoxymacropodumine d导致含连续五年立构中心的ABC三环框架的高效制备。这项合成工作的特点是：（1）利用不对称共轭加成物来安装C5全碳四元中心，（2）分子内氮杂-Michael加成反应，然后进行Pd催化的α-烯基化反应以构建碗形三环核。