A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available chiral auxiliary. The practicality of this transformation is demonstrated on a multi-gram scale.

中文翻译：

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磷在到达合成GSK2248761A的关键中间体的过程中具有高度非对映选择性的氯化物介导的动力学动力学拆分

已经开发了一种在磷中具有高度非对映选择性的氯化物介导的动态动力学拆分方法，可用于合成GSK2248761A的关键中间体。该方法利用了可溶的氯化物源和便宜的容易获得的手性助剂。这种转换的实用性以克为单位进行了演示。