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A selective glucose sensor: the cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-04-09 00:00:00 , DOI: 10.1039/c8cc00914g
Ching-Hua Tsai,Yi-Hsuan Tang,Hui-Ting Chen,Yi-Wen Yao,Tun-Cheng Chien,Chai-Lin Kao

Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

中文翻译:

选择性葡萄糖传感器:单硼酸修饰的聚(酰胺基胺)树状聚合物的协同作用

通过五代单硼酸官能化的PAMAM树状聚合物鉴定了选择性葡萄糖结合。当使用G3树状聚合物(1b)时,获得的最佳选择性分别比使用半乳糖,果糖和乳糖时强71.1、94.9和1309倍。使用树枝状大分子类似物和葡萄糖衍生物的进一步实验表明,附近的两个单硼酸协同结合一个葡萄糖。
更新日期:2018-04-09
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