The new [3+3] NH-CH₂ bridged cyclophanes bearing different functional groups and different cavity sizes were prepared in one pot by treating diamine derivatives with dialdehyde derivatives. Factors important for efficiently form-ing these macrocycles include reaction concentration (10 or 100 mmol), temperature (room temperature or 40-50 °C) and solvent (CHCl₃). Preliminary fluorescence spectrometer and HRMS-ESI studies demonstrated the inner cavity of the new [3+3] NH-CH₂ bridged cyclophanes bearing three hydroxyl groups (3c) as a new highly selective probe for the naked eye detection of Ag⁺ in PBS buffer.

中文翻译：

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新型[3 + 3] NH-CH ₂桥联环烷的一锅形成

通过用二醛衍生物处理二胺衍生物，在一个罐中制备了具有不同官能团和不同空腔尺寸的新的[3 + 3] NH-CH ₂桥接的环烷。有效形成这些大环重要的因素包括反应浓度（10或100 mmol），温度（室温或40-50°C）和溶剂（CHCl ₃）。初步的荧光光谱仪和HRMS-ESI研究表明，带有3个羟基（3c）的新型[3 + 3] NH-CH ₂桥联环烷的内腔是用于肉眼检测PBS缓冲液中Ag ⁺的新型高选择性探针。