A two-step sequence was developed for the synthesis of chromeno[4′,3′:4,5]pyrido[1,2- a ]pyrazine-13-carboxylates and -diazepine-14-carboxylates by the reaction of substituted dimethyl 2-(3-acetyl-2-oxo-2 H -chromen-4-yl)fumarates with 1, n -diamines at room temperature. Advantages of this protocol include ease of handling and the absence of a metal catalyst.

中文翻译：

---

取代的 2-(3-Acetyl-2-oxo-2H-chromen-4-yl) 反应合成 Chromeno[4',3':4,5]pyrido[1,2-a]pyrazines 和 -diazepines富马酸盐与 1,n-二胺

通过取代二甲基 2 的反应，开发了用于合成 chromeno[4',3':4,5]pyrido[1,2-a]pyrazine-13-carboxylates 和 -diazepine-14-carboxylates 的两步序列-(3-acetyl-2-oxo-2 H -chromen-4-yl)fumarates 与 1, n-二胺在室温下。该协议的优点包括易于处理和没有金属催化剂。