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Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery
Optica ( IF 10.4 ) Pub Date : 2018-04-05 , DOI: 10.1364/optica.5.000413
Missael Garcia , Christopher Edmiston , Timothy York , Radoslav Marinov , Suman Mondal , Nan Zhu , Gail P. Sudlow , Walter J. Akers , Julie Margenthaler , Samuel Achilefu , Rongguang Liang , Mohamed A. Zayed , Marta Y. Pepino , Viktor Gruev

Image-guided surgery can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky and costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities for distinguishing cancerous from healthy tissue. Here we introduce an innovative design, comprising an artificial multispectral sensor inspired by the Morpho butterfly’s compound eye, which can significantly improve image-guided surgery. By monolithically integrating spectral tapetal filters with photodetectors, we have realized a single-chip multispectral imager with 1000× higher sensitivity and 7× better spatial co-registration accuracy compared to clinical imaging systems in current use. Preclinical and clinical data demonstrate that this technology seamlessly integrates into the surgical workflow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes. Due to its low manufacturing cost, our bio-inspired sensor will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care.

中文翻译:

受生物启发的成像仪可提高近红外荧光成像引导手术的敏感性

图像引导手术可通过减少并理想地消除阳性肿瘤切缘和对健康组织的医源性损害来增强癌症治疗。当前最新的近红外荧光成像系统体积庞大且昂贵,在手术照明下缺乏灵敏度,并且在多模态图像之间缺乏共配准精度。结果,绝大多数医生仍将其肉眼和触诊作为区分癌组织与健康组织的主要方法。在这里,我们介绍一种创新的设计,其中包括一个受Morpho启发的人工多光谱传感器蝴蝶的复眼,可显着改善影像引导手术。通过将光谱带滤光片与光电探测器单片集成,我们实现了具有以下功能的单芯片多光谱成像仪:1000× 更高的灵敏度和 7×与当前使用的临床成像系统相比,具有更好的空间共配准精度。临床前和临床数据表明,该技术无缝集成到手术流程中,同时为外科医生提供癌组织和前哨淋巴结位置的实时信息。由于其制造成本低,我们的生物启发传感器将为资源有限的医院提供急需的技术,以实现更准确的基于价值的医疗保健。
更新日期:2018-04-23
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