Several synthetic efforts are reported towards the optically active (−)-prosophylline and (+)-prosophylline, and their derivatives. Interestingly and surprisingly, although only a few synthesis are reported for the parent molecules, there are more reports for the synthesis of their derivatives such as deoxoprosophyllines, deoxoprosopinines, deoxocassines etc. The three main strategies to procure these molecules in optically pure forms are by using (i) chiral synthons (ii) chiral auxiliaries and (iii) asymmetric catalysis. Among these, the chiral synthons are mainly utilized by a number of researchers. This review summarizes the recent developments in the synthesis of optically active prosophyllines and their derivatives, and covers the literature from the year 2000 onwards.

据报道，对光学活性（-）-脯氨酸和（+）-脯氨酸及其衍生物进行了一些合成努力。有趣且令人惊讶的是，尽管仅报道了一些母体分子的合成方法，但仍有更多关于其衍生物如脱氧脯氨酸，脱氧胸苷，脱氧胞嘧啶等的合成的报道。以光学方式获得这些分子的三种主要策略是通过使用（i）手性合成子（ii）手性助剂和（iii）不对称催化。其中，手性合成子主要被许多研究人员利用。这篇综述总结了旋光活性脯氨酸及其衍生物的合成的最新进展，并涵盖了2000年以后的文献。