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Dishevelled: A masterful conductor of complex Wnt signals
Cellular Signalling ( IF 4.8 ) Pub Date : 2018-03-17 , DOI: 10.1016/j.cellsig.2018.03.004
Monica Sharma , Isabel Castro-Piedras , Glenn E. Simmons , Kevin Pruitt

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [[1], [2], [3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [[5], [6], [7], [8], [9], [10]]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.



中文翻译:

混乱:复杂Wnt信号的熟练指挥

Disheveled基因最早是在果蝇的突变体中发现的,这些突变体的头发和鬃毛的方向都错位了[[1],[2],[3]]。该DSH基因(DSH / DVL,在果蝇和脊椎动物分别)得到普及时,人们发现它在段极性早期胚胎发育过程中起关键作用的果蝇[4]。随后,在非洲爪蟾Xdsh),小鼠(Dvl1,Dvl2,Dvl3)和人(DVL1,DVL2,DVL3)中鉴定了Disheveled基因的脊椎动物同源物。)[[5],[6],[7],[8],[9],[10]]。杂乱无章的功能是Wnt信号通路的主要组成部分,并控制着几种细胞过程,包括细胞增殖,存活,迁移,分化,极性和干细胞更新。这篇综述将重温开创性的发现,并总结表征Disheveled在正常和病理生理环境中的作用的最新进展。

更新日期:2018-03-17
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