Biotransformation of 6-methylthiochroman-4-one (1) and 6-chlorothiochroman-4-one (2) was performed using Trichoderma viride in order to obtain new derivatives with antifungal properties against the phytopathogen Botrytis cinerea. Two thiochromanone derivatives are described for the first time. Antifungal activity of these compounds was tested against two different strains of Botrytis cinerea; 1 and 2 gave 100% inhibition of Bc2100 at 100–250 μg/mL, and 3 gave a maximal inhibition of 96% of BcUCA992 at 200 μg/mL. The detoxification mechanism of 1 and 2 by B. cinerea was also investigated.

中文翻译：

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绿色木霉和灰霉菌对抗真菌硫代色氨酸-4-酮的代谢

生物转化的6-甲基thiochroman-4-one（1）和6-chlorothiochroman-4-one（2）使用木霉进行了生物降解，以获得具有抗真菌特性的植物灰霉病灰霉病的新衍生物。首次描述了两种硫代苯并二氢吡喃酮衍生物。测试了这些化合物对灰霉病菌的两种不同菌株的抑菌活性; 1和2在100–250μg/ mL时对Bc 2100的抑制率为100％，而在3μg/ mL中，3和3对Bc UCA992的抑制率最大。的解毒机制1和2由灰葡萄孢菌也进行了研究。