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MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma
Microchimica Acta ( IF 5.7 ) Pub Date : 2018-04-01 , DOI: 10.1007/s00604-018-2779-5
Junxin Lai , Tingjian Wang , Hao Wang , Fengqiang Shi , Wei Gu , Ling Ye

AbstractThe authors describe MnO nanoparticles (NPs) with unique excitation-dependent fluorescence across the entire visible spectrum. These NPs are shown to be efficient optical nanoprobe for multicolor cellular imaging. Synthesis of the NPs is accomplished by a thermal decomposition method. The MnO NPs exhibit a high r1 relaxivity of 4.68 mM−1 s−1 and therefore give an enhanced contrast effect in magnetic resonance (MR) studies of brain glioma. The cytotoxicity assay, hemolysis analysis, and hematoxylin and eosin (H&E) staining tests verify that the MnO NPs are biocompatible. In the authors’ perception, the simultaneous attributes of multicolor fluorescence and excellent MR functionality make this material a promising dual-modal nanoprobe for use in bio-imaging. Graphical abstractA direct method to synthesize fluorescent MnO NPs is reported. The NPs are biocompatible and have been successfully applied for multicolor cellular imaging and MR detection of brain glioma.

中文翻译:

具有独特激发依赖性荧光的 MnO 纳米颗粒用于脑胶质瘤的多色细胞成像和 MR 成像

摘要作者描述了在整个可见光谱范围内具有独特激发依赖性荧光的 MnO 纳米粒子 (NPs)。这些纳米颗粒被证明是用于多色细胞成像的高效光学纳米探针。NPs的合成是通过热分解方法完成的。MnO NPs 表现出 4.68 mM-1 s-1 的高 r1 弛豫率,因此在脑胶质瘤的磁共振 (MR) 研究中提供增强的对比效果。细胞毒性测定、溶血分析以及苏木精和伊红 (H&E) 染色测试验证了 MnO NPs 是生物相容性的。在作者看来,多色荧光和优异的 MR 功能的同时属性使这种材料成为用于生物成像的有前途的双模式纳米探针。图形摘要报告了合成荧光 MnO NPs 的直接方法。
更新日期:2018-04-01
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